This Week’s Most Viewed Papers
Each day thousands of Academia.edu users scour the site, discovering new research topics and catching wind of trending papers.
Here’s what captured the curiosity of Academia.edu users this week:
Using plant extracts to create cancer fighting nanoparticles
Total Views: 1,706
Biofunctionalized gold and silver nanoparticles synthesized using different plant extracts of guava and clove in vitro anti-cancer efficacy against four different cancer cell lines human colorectal adenocarcinoma, human kidney, human chronic myelogenous, leukemia, bone marrow, and human cervix have been studied and reported. The present experimental study suggests that flavonoids functionalized gold nanoparticles synthesized using aqueous clove buds extract are more potential than guava leaf extract towards anti-cancer activities. The study revealed that the free radicals generated by gold nanoparticles are responsible for anti-cancer effect. To confirm the free-radical scavenging efficacy of gold nanoparticle, nitric oxide assay is followed. We observed that the gold nanoparticles swabbed the free radicals in dose-dependent manner. With continued improvements, these nanoparticles may prove to be potential anti-cancer agents.
Understanding T-cells in the fight against HIV
Total Views: 3
We demonstrate that human Treg cells isolated from healthy donors express the HIV-coreceptor CCR5 and are highly susceptible to HIV infection and replication. Targeting and disruption of the T-cell regulatory system by HIV may contribute to hyperactivation of conventional T-cells, a characteristic of HIV disease progression. Moreover, the ability to reprogram human T-cells into Treg cells in vitro will greatly aid in decoding their mechanism of suppression, their enhanced susceptibility to HIV infection, and the unique markers expressed by this subset.
Masculinity and Nigerian Youths
Total Views: 46
This paper considers the masculine views of a cross-section of Nigerian youths or, more precisely, undergraduates, to determine the forms of masculinity among youths. Drawn from different ethnic groups the masculine notions of the category of young men represented in this study show both similarities and differences. Influenced by the university environment, which promotes cross-cultural mingling and exchange of ideas, the views of the study participants are combinations of indigenous and non-indigenous masculine notions but reshaped by the economic and social changes that have taken place in the last two to three decades in the country. Youths aspire to project an ideal masculine identity as they grow older. They regard their educational pursuits as a preparatory phase for actualizing their dream personality. A pointer from this study is that masculine gender expressions cannot be generalized. Individual views can vary widely and are strongly affected by traditional practice as well as environmental and other realities.
Total Views: 2,396
Tissue engineering has been a promising field of research, offering hope for bridging the gap between organ shortage and transplantation needs. However, building three-dimensional (3D) vascularized organs remains the main technological barrier to be overcome. Organ printing, which is defined as computer-aided additive biofabrication of 3D cellular tissue constructs, has shed light on advancing this field into a new era. Organ printing takes advantage of rapid prototyping (RP) technology to print cells, biomaterials, and cell-laden biomaterials individually or in tandem, layer by layer, directly creating 3D tissue-like structures. Here, we overview RP-based bioprinting approaches and discuss the current challenges and trends towards fabricating living organs for transplant in the near future
Assessing the health of animals fed GMO Corn
Total Views: 28
Histopathological examination of liver, kidney, spleen, pancreas, duodenum, jejunum, skeletal muscle, and bursa of Fabricius samples, collected from broiler chickens, laying hens, fattening pigs, and calves fed genetically modified corn MON 810 and soybean meal MON-40-3-2 (Roundup Ready, RR), was performed. The examination showed no significant differences between the control animals fed diets containing no genetically modified feeds and animals fed genetically modified feeds. In some cases, congestion of parenchyma and focal lymphoid cell infiltrations were observed in all dietary groups, including controls, and therefore, it was assumed that the lesions were not associated with the feeding transgenic feed.
Blombos Cave: Lair of Our Ancestor Shellfishers
Author: Cheryl Lyn DYBAS
Total Views: 23
When the earliest humans mastered the art of conceptualising, creating and storing items that enhanced their lives, such as tools or physical ornamentation, a milestone in our evolution was reached. That milestone appears to have been passed far earlier than we thought, and not in Europe, but in Africa.
Total Views: 53
Venus is often overlooked as a target for settlement or terraforming because of its extreme environment, which is the result of a massive and dense super-greenhouse atmosphere. This paper presents a scenario in which Venus could be made habitable and ready for settlement in only a few centuries, based primarily on ideas put forward by Paul Birch in 1991.
How the media is covering Fracking
Total Views: 245
Shale gas is a novel source of fossil fuel which is extracted by induced hydraulic fracturing, or “fracking”. In this article, we examine the emergence of and inter-relations between competing social representations, discuss the dynamics of threat positioning and show how threat can be re-construed in order to serve particular socio-political ends in the debate on fracking.
Electrospraying cells to create stem cells
Author: Sambit Sahoo, Cleveland Clinic
Total Views: 10
Bio-electrospraying is fast becoming an attractive tool for in situ cell delivery into scaffolds for tissue engineering applications, with several cell types been successfully electrosprayed. Bone marrow derived mesenchymal progenitor/stem cells (BMSC), which are an important cell source for tissue engineering, have not been explored in detail and the effect of electrospraying on their “stemness” is not known. This study therefore investigates the effects of electrospraying on BMSC viability, proliferation, and multi-lineage differentiation potential.
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